TLSI
TriSalus Life Sciences, Inc. (TLSI) Economic Moat Analysis (2026)
Overall Score
Profitability Returns
TTM margins are deeply negative, with EBIT margin at -49.6% and net profit margin at -62.6%, indicating the business is still far from durable profitability.
Returns remain poor, with ROIC at -59.2% and ROA at -45.2%, suggesting no evidence of a strong economic moat in current operations.
Gross margin is high at 85.8%, but it is not translating into operating leverage given the negative operating and EBITDA margins.
Balance Sheet Cash Generation
Liquidity is strong, with a current ratio of 5.35 and cash ratio of 4.14, which reduces near-term solvency risk.
Cash generation is weak, as operating cash flow and free cash flow are both negative on a TTM basis, with FCF yield at -10.1%.
Leverage is moderate, with debt-to-equity at 5.26 and net debt to EBITDA at 0.55, but negative EBITDA makes leverage metrics less meaningful.
Moat Evidence Competitive Position
There is no clear evidence of pricing power or durable moat from the current TTM results, since high gross margin is offset by weak operating performance.
Asset efficiency is mixed, with fixed asset turnover strong at 17.1 but overall asset turnover only 0.72, implying limited broad-based efficiency.
The company’s negative earnings and cash flow profile suggests competitive advantages are not yet visible in financial outcomes.
Valuation Vs Moat
The stock trades at a rich sales multiple of 6.6x EV/Sales despite negative EBITDA, negative free cash flow, and negative earnings.
Price-to-book is extremely high at 43.0x, which leaves little margin of safety for a business without demonstrated moat durability.
Valuation appears to assume a future turnaround, but current fundamentals do not yet support a moat-based premium.
Sources
- Company filings (10-K, 10-Q, investor presentations)
- Financial and market data providers
- Public news and industry information
🔒 Go Beyond This Framework
This is one of 10 institutional-grade frameworks Invetso runs on TriSalus Life Sciences, Inc.. Unlock the complete analysis — SWOT, Economic Moat, Porter’s Five Forces, Management, PESTLE and the Invetso Quality Score.

